2I0A

Crystal Structure of KB-19 complexed with wild type HIV-1 protease

2I0A の概要

• エントリーDOI: 10.2210/pdb2i0a/pdb
• 関連するPDBエントリー: 1F7A 2I0D
• 分子名称: Protease, PHOSPHATE ION, (5S)-3-(4-ACETYLPHENYL)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]-2-OXO-1,3-OXAZOLIDINE-5-CARBOXAMIDE, ... (5 entities in total)
• 機能のキーワード: drug design, hiv-1 protease, protease inhibitors, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22741.30

構造登録者

Nalam, M.N.L.,Schiffer, C.A.,Ali, A.,Reddy, K.K.,Cao, H.,Anjum, S.G.,Rana, T.M. (登録日: 2006-08-10, 公開日: 2006-12-19, 最終更新日: 2023-08-30)

• 主引用文献: Ali, A.,Reddy, G.S.,Cao, H.,Anjum, S.G.,Nalam, M.N.,Schiffer, C.A.,Rana, T.M.; Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands.; J.Med.Chem., 49:7342-7356, 2006; PubMed: 17149864; DOI: 10.1021/jm060666p

実験手法

X-RAY DIFFRACTION (1.8 Å)