2HY8

PAK1 complex with ST2001

Summary for 2HY8

• Entry DOI: 10.2210/pdb2hy8/pdb
• Related: 1YHV 1YHW
• Descriptor: Serine/threonine-protein kinase PAK 1, (5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[ B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE (3 entities in total)
• Functional Keywords: typical fold of ser/thr kinases. inhibitor is bound between the n-terminal and c-terminal domains., transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q13153
• Total number of polymer chains: 1
• Total formula weight: 33781.76

Authors

Schulze-Gahmen, U.,Lu, H. (deposition date: 2006-08-04, release date: 2006-11-07, Last modification date: 2024-02-14)

• Primary citation: Lu, H.,Lei, M.,Schulze-Gahmen, U.; Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)