2HY0
crystal structure of chek1 in complex with inhibitor 22
Summary for 2HY0
Entry DOI | 10.2210/pdb2hy0/pdb |
Related | 2HXL 2HXQ |
Descriptor | Serine/threonine-protein kinase Chk1, 3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-6-(1H-PYRAZOL-4-YL)QUINOLIN-2(1H)-ONE (3 entities in total) |
Functional Keywords | chek1, kinase, cell cycle checkpoint, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 37214.47 |
Authors | |
Primary citation | Huang, S.,Garbaccio, R.M.,Fraley, M.E.,Steen, J.,Kreatsoulas, C.,Hartman, G.,Stirdivant, S.,Drakas, B.,Rickert, K.,Walsh, E.,Hamilton, K.,Buser, C.A.,Hardwick, J.,Mao, X.,Abrams, M.,Beck, S.,Tao, W.,Lobell, R.,Sepp-Lorenzino, L.,Yan, Y.,Ikuta, M.,Murphy, J.Z.,Sardana, V.,Munshi, S.,Kuo, L.,Reilly, M.,Mahan, E. Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg.Med.Chem.Lett., 16:5907-5912, 2006 Cited by PubMed: 16990002DOI: 10.1016/j.bmcl.2006.08.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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