2HX2

Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine

Summary for 2HX2

Related2HX3 2HX4
DescriptorNitric-oxide synthase, CACODYLATE ION, ACETATE ION, ... (9 entities in total)
Functional Keywordsnitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
Biological sourceBos taurus (cattle)
Cellular locationCell membrane P29473
Total number of polymer chains2
Total molecular weight96709.87
Authors
Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2006-08-02, release date: 2007-04-24, Last modification date: 2011-07-13)
Primary citation
Seo, J.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50:2089-2099, 2007
PubMed: 17425297 (PDB entries with the same primary citation)
DOI: 10.1021/jm061305c
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.207602.9%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report