2HWK

Crystal Structure of Venezuelan Equine Encephalitis Alphavirus nsP2 Protease Domain

2HWK の概要

• エントリーDOI: 10.2210/pdb2hwk/pdb
• 分子名称: helicase nsP2, FORMIC ACID (3 entities in total)
• 機能のキーワード: rossmann fold, alpha/beta/alpha, multi-domain, hydrolase
• 由来する生物種: Venezuelan equine encephalitis virus (strain TC-83)
• 細胞内の位置: Non-structural polyprotein: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . mRNA-capping enzyme nsP1: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase nsP4: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : P27282
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36377.49

構造登録者

Russo, A.T.,White, M.A.,Watowich, S.J. (登録日: 2006-08-01, 公開日: 2006-09-26, 最終更新日: 2024-02-14)

• 主引用文献: Russo, A.T.,White, M.A.,Watowich, S.J.; The Crystal Structure of the Venezuelan Equine Encephalitis Alphavirus nsP2 Protease.; Structure, 14:1449-1458, 2006; PubMed: 16962975; DOI: 10.1016/j.str.2006.07.010

実験手法

X-RAY DIFFRACTION (2.45 Å)