2HVX

Discovery of Potent, Orally Active, Nonpeptide Inhibitors of Human Mast Cell Chymase by Using Structure-Based Drug Design

2HVX の概要

• エントリーDOI: 10.2210/pdb2hvx/pdb
• 分子名称: Chymase, [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID (3 entities in total)
• 機能のキーワード: serine protease, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P23946
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25423.69

構造登録者

Greco, M.N.,Hawkins, M.J.,Powell, E.T.,Almond, H.R.,de Garavilla, L.,Wang, Y.,Minor, L.A.,Wells, G.I.,Di Cera, E.,Cantwell, A.M.,Savvides, S.N.,Damiano, B.P.,Maryanoff, B.E. (登録日: 2006-07-31, 公開日: 2007-06-12, 最終更新日: 2021-10-20)

• 主引用文献: Greco, M.N.,Hawkins, M.J.,Powell, E.T.,Almond, H.R.,de Garavilla, L.,Hall, J.,Minor, L.K.,Wang, Y.,Corcoran, T.W.,Di Cera, E.,Cantwell, A.M.,Savvides, S.N.,Damiano, B.P.,Maryanoff, B.E.; Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.; J.Med.Chem., 50:1727-1730, 2007; PubMed: 17361995; DOI: 10.1021/jm0700619

実験手法

X-RAY DIFFRACTION (2.6 Å)