2HVP

THREE-DIMENSIONAL STRUCTURE OF ASPARTYL PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS HIV-1

2HVP の概要

• エントリーDOI: 10.2210/pdb2hvp/pdb
• 分子名称: HIV-1 PROTEASE (1 entity in total)
• 機能のキーワード: hydrolase(acid proteinase)
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10830.78

構造登録者

Navia, M.A.,Fitzgerald, P.M.D.,Mckeever, B.M.,Springer, J.P. (登録日: 1989-04-10, 公開日: 1989-04-19, 最終更新日: 2024-02-14)

主引用文献

Navia, M.A.,Fitzgerald, P.M.,McKeever, B.M.,Leu, C.T.,Heimbach, J.C.,Herber, W.K.,Sigal, I.S.,Darke, P.L.,Springer, J.P.
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.
Nature, 337:615-620, 1989

PubMed Abstract: The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 A resolution. Large regions of the protease dimer, including the active site, have structural homology to the family of microbial aspartyl proteases. The structure suggests a mechanism for the autoproteolytic release of protease and a role in the control of virus maturation.

PubMed: 2645523
DOI: 10.1038/337615a0

実験手法

X-RAY DIFFRACTION (3 Å)