2HV9

Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase in complex with sinefungin

2HV9 の概要

• エントリーDOI: 10.2210/pdb2hv9/pdb
• 関連するPDBエントリー: 1ri1 1ri2 1ri3 1ri4 1ri5 1z3c
• 分子名称: mRNA cap guanine-N7 methyltransferase, SINEFUNGIN (3 entities in total)
• 機能のキーワード: mrna, cap, methyltransferase, inhibitor, transferase
• 由来する生物種: Encephalitozoon cuniculi
• 細胞内の位置: Nucleus (By similarity): Q8SR66
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35205.07

構造登録者

Lima, C.D. (登録日: 2006-07-27, 公開日: 2006-09-19, 最終更新日: 2023-08-30)

• 主引用文献: Zheng, S.,Hausmann, S.,Liu, Q.,Ghosh, A.,Schwer, B.,Lima, C.D.,Shuman, S.; Mutational Analysis of Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity; J.Biol.Chem., 281:35904-35913, 2006; PubMed: 16971388; DOI: 10.1074/jbc.M607292200

実験手法

X-RAY DIFFRACTION (2.6 Å)