2HUW

X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand

2HUW の概要

• エントリーDOI: 10.2210/pdb2huw/pdb
• 分子名称: Growth factor receptor-bound protein 2, N-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-L-valyl-L-aspartamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: cylcopropane, contrained, grb2, sh2, preorganization, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : P62993
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28524.83

構造登録者

Benfield, A.P.,Martin, S.F. (登録日: 2006-07-27, 公開日: 2006-08-15, 最終更新日: 2024-02-14)

• 主引用文献: Benfield, A.P.,Teresk, M.G.,Plake, H.R.,Delorbe, J.E.,Millspaugh, L.E.,Martin, S.F.; Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.; Angew.Chem.Int.Ed.Engl., 45:6830-6835, 2006; PubMed: 17001728; DOI: 10.1002/anie.200600844

実験手法

X-RAY DIFFRACTION (1.9 Å)