2HSG

Structure of transcription regulator CcpA in its DNA-free state

2HSG の概要

• エントリーDOI: 10.2210/pdb2hsg/pdb
• 関連するPDBエントリー: 1RZR 1SHI 1SXG 1SXH 1ZVV 2FEP
• 分子名称: Glucose-resistance amylase regulator (1 entity in total)
• 機能のキーワード: ccpa, transcriptional regulator, transcription regulator
• 由来する生物種: Bacillus megaterium
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36685.65

構造登録者

Loll, B.,Alings, C.,Saenger, W.,Biesiadka, J. (登録日: 2006-07-21, 公開日: 2007-06-05, 最終更新日: 2023-08-30)

主引用文献

Loll, B.,Saenger, W.,Biesiadka, J.
Structure of full-length transcription regulator CcpA in the apo form.
Biochim.Biophys.Acta, 1774:732-736, 2007

PubMed Abstract: The catabolite control protein A (CcpA) from Bacillus megaterium is a member of the bacterial repressor protein family GalR-LacI. CcpA functions as master transcriptional regulator of carbon catabolite repression/regulation in firmicutes. Here we present the crystal structure of full-length apo CcpA at 2.5 A resolution from B. megaterium. The structure reveals the location of the helix-turn-helix domain as well as the hinge region, which were not visible due to their high flexibility in earlier crystallographic studies on CcpA molecules. The structure of the apo CcpA homodimer in the present form is in contrast to other reported structures for CcpA.

PubMed: 17500051
DOI: 10.1016/j.bbapap.2007.03.020

実験手法

X-RAY DIFFRACTION (2.5 Å)