2HR6

Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese

Summary for 2HR6

Entry DOI	10.2210/pdb2hr6/pdb
Descriptor	Deoxyuridine 5'-triphosphate nucleotidohydrolase, MANGANESE (II) ION, DEOXYURIDINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	jelly roll, enzyme-ligand-metal complex, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	16807.78
Authors	Barabas, O.,Kovari, J.,Tapai, R.,Vertessy, B.G. (deposition date: 2006-07-19, release date: 2007-07-31, Last modification date: 2023-08-30)
Primary citation	Kovari, J.,Barabas, O.,Varga, B.,Bekesi, A.,Tolgyesi, F.,Fidy, J.,Nagy, J.,Vertessy, B.G. Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site. Proteins, 71:308-319, 2008 Cited by PubMed: 17932923 DOI: 10.1002/prot.21757 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation