2HQH

Crystal structure of p150Glued and CLIP-170

2HQH の概要

• エントリーDOI: 10.2210/pdb2hqh/pdb
• 関連するPDBエントリー: 1TXQ
• 分子名称: Dynactin-1, Restin, ZINC ION, ... (4 entities in total)
• 機能のキーワード: beta/beta structure, zinc finger motif, structural protein, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : Q14203 P30622
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 51686.63

構造登録者

Hayashi, I.,Ikura, M. (登録日: 2006-07-18, 公開日: 2007-08-21, 最終更新日: 2024-02-14)

主引用文献

Hayashi, I.,Plevin, M.J.,Ikura, M.
CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.
Nat.Struct.Mol.Biol., 14:980-981, 2007

PubMed Abstract: CLIP170 and p150(Glued) localize to the plus ends of growing microtubules. Using crystallography and NMR, we show that autoinhibitory interactions within CLIP170 use the same binding determinants as CLIP170's intermolecular interactions with p150(Glued). These interactions have both similar and distinct features when compared with the p150(Glued)-EB1 complex. Our data thus demonstrate that regulation of microtubule dynamics by plus end-tracking proteins (+TIPs) occurs through direct competition between homologous binding interfaces.

PubMed: 17828275
DOI: 10.1038/nsmb1299

実験手法

X-RAY DIFFRACTION (1.8 Å)