2HOG
crystal structure of Chek1 in complex with inhibitor 20
Summary for 2HOG
Entry DOI | 10.2210/pdb2hog/pdb |
Descriptor | Serine/threonine-protein kinase Chk1, (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL (3 entities in total) |
Functional Keywords | chek1, kinase, cell cycle checkpoint, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 37218.46 |
Authors | |
Primary citation | Fraley, M.E.,Steen, J.T.,Brnardic, E.J.,Arrington, K.L.,Spencer, K.L.,Hanney, B.A.,Kim, Y.,Hartman, G.D.,Stirdivant, S.M.,Drakas, B.A.,Rickert, K.,Walsh, E.S.,Hamilton, K.,Buser, C.A.,Hardwick, J.,Tao, W.,Beck, S.C.,Mao, X.,Lobell, R.B.,Sepp-Lorenzino, L.,Yan, Y.,Ikuta, M.,Munshi, S.K.,Kuo, L.C.,Kreatsoulas, C. 3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6. Bioorg.Med.Chem.Lett., 16:6049-6053, 2006 Cited by PubMed: 16978863DOI: 10.1016/j.bmcl.2006.08.118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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