2HND

Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine

2HND の概要

• エントリーDOI: 10.2210/pdb2hnd/pdb
• 分子名称: Reverse transcriptase/ribonuclease H, PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, nevirapine, drug resistance mutations, drug design, transferase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 111943.02

構造登録者

Ren, J.,Nichols, C.E.,Stamp, A.,Chamberlain, P.P.,Stammers, D.K. (登録日: 2006-07-12, 公開日: 2006-09-05, 最終更新日: 2021-10-20)

• 主引用文献: Ren, J.,Nichols, C.E.,Stamp, A.,Chamberlain, P.P.,Ferris, R.,Weaver, K.L.,Short, S.A.,Stammers, D.K.; Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.; Febs J., 273:3850-3860, 2006; PubMed: 16911530; DOI: 10.1111/j.1742-4658.2006.05392.x

実験手法

X-RAY DIFFRACTION (2.5 Å)