2HIZ

Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor

2HIZ の概要

• エントリーDOI: 10.2210/pdb2hiz/pdb
• 分子名称: Beta-secretase 1, PHOSPHATE ION, BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE, ... (4 entities in total)
• 機能のキーワード: protein-inhibitor complex, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 153040.24

構造登録者

Benson, T.E.,Prince, D.B.,Tomasselli, A.G.,Emmons, T.L.,Paddock, D.J. (登録日: 2006-06-29, 公開日: 2007-01-23, 最終更新日: 2017-10-18)

• 主引用文献: Freskos, J.N.,Fobian, Y.M.,Benson, T.E.,Bienkowski, M.J.,Brown, D.L.,Emmons, T.L.,Heintz, R.,Laborde, A.,McDonald, J.J.,Mischke, B.V.,Molyneaux, J.M.,Moon, J.B.,Mullins, P.B.,Bryan Prince, D.,Paddock, D.J.,Tomasselli, A.G.,Winterrowd, G.; Design of potent inhibitors of human beta-secretase. Part 1.; Bioorg.Med.Chem.Lett., 17:73-77, 2007; PubMed: 17046251; DOI: 10.1016/j.bmcl.2006.09.092

実験手法

X-RAY DIFFRACTION (2.5 Å)