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2HHH

Crystal structure of kasugamycin bound to the 30S ribosomal subunit

Summary for 2HHH
Entry DOI10.2210/pdb2hhh/pdb
Descriptor16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (22 entities in total)
Functional Keywordsribosome, 30s, antibiotics, initiation
Biological sourceThermus thermophilus
More
Total number of polymer chains21
Total formula weight784440.75
Authors
Schluenzen, F. (deposition date: 2006-06-28, release date: 2006-09-26, Last modification date: 2024-02-14)
Primary citationSchluenzen, F.,Takemoto, C.,Wilson, D.N.,Kaminishi, T.,Harms, J.M.,Hanawa-Suetsugu, K.,Szaflarski, W.,Kawazoe, M.,Shirouzo, M.,Nierhaus, K.H.,Yokoyama, S.,Fucini, P.
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.
Nat.Struct.Mol.Biol., 13:871-878, 2006
Cited by
PubMed: 16998488
DOI: 10.1038/nsmb1145
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.35 Å)
Structure validation

217705

数据于2024-03-27公开中

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