2HH9

Thiamin pyrophosphokinase from Candida albicans

Summary for 2HH9

• Entry DOI: 10.2210/pdb2hh9/pdb
• Related: 2G9Z
• Descriptor: Thiamin pyrophosphokinase, MAGNESIUM ION, 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, ... (4 entities in total)
• Functional Keywords: thiamin, tpk, thiamin pyrophosphokinase, structural genomics, bacterial targets at igs-cnrs, france, bigs, transferase
• Biological source: Candida albicans
• Total number of polymer chains: 2
• Total formula weight: 78418.52

Authors

Abergel, C.,Santini, S.,Monchois, V.,Rousselle, T.,Claverie, J.M.,Bacterial targets at IGS-CNRS, France (BIGS) (deposition date: 2006-06-28, release date: 2006-07-18, Last modification date: 2023-10-25)

Primary citation

Santini, S.,Monchois, V.,Mouz, N.,Sigoillot, C.,Rousselle, T.,Claverie, J.M.,Abergel, C.
Structural characterization of CA1462, the Candida albicans thiamine pyrophosphokinase.
Bmc Struct.Biol., 8:33-33, 2008

PubMed Abstract: In search of new antifungal targets of potential interest for pharmaceutical companies, we initiated a comparative genomics study to identify the most promising protein-coding genes in fungal genomes. One criterion was the protein sequence conservation between reference pathogenic genomes. A second criterion was that the corresponding gene in Saccharomyces cerevisiae should be essential. Since thiamine pyrophosphate is an essential product involved in a variety of metabolic pathways, proteins responsible for its production satisfied these two criteria.

PubMed: 18652651
DOI: 10.1186/1472-6807-8-33

Experimental method

X-RAY DIFFRACTION (2.1 Å)