2HFU

Crystal structure of L. major mevalonate kinase in complex with R-mevalonate

2HFU の概要

• エントリーDOI: 10.2210/pdb2hfu/pdb
• 関連するPDBエントリー: 2hfs
• 分子名称: Mevalonate kinase, putative, (R)-MEVALONATE (3 entities in total)
• 機能のキーワード: ghmp kinase, mevalonate kinase, trypanosomatid parasite, transferase
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71770.67

構造登録者

Sgraja, T.,Hunter, W.N. (登録日: 2006-06-26, 公開日: 2007-04-17, 最終更新日: 2024-04-03)

主引用文献

Sgraja, T.,Smith, T.K.,Hunter, W.N.
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase.
Bmc Struct.Biol., 7:20-20, 2007

PubMed Abstract: Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information available on the structure and reactivity of the component enzymes in trypanosomatids. Since isoprenoid biosynthesis is essential for trypanosomatid viability and may provide new targets for therapeutic intervention it is important to characterize the pathway components.

PubMed: 17397541
DOI: 10.1186/1472-6807-7-20

実験手法

X-RAY DIFFRACTION (2 Å)