2HEJ

Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP(H) in a closed conformation

Summary for 2HEJ

Entry DOI	10.2210/pdb2hej/pdb
Related	2HDJ 2HE5 2HE8
Descriptor	Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, closed conformation, oxidoreductase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	76042.95
Authors	Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-06-21, release date: 2006-12-05, Last modification date: 2023-08-30)
Primary citation	Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R. Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme. J.Mol.Biol., 364:747-763, 2006 Cited by PubMed: 17034817 DOI: 10.1016/j.jmb.2006.09.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation