2HEJ

Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP(H) in a closed conformation

2HEJ の概要

• エントリーDOI: 10.2210/pdb2hej/pdb
• 関連するPDBエントリー: 2HDJ 2HE5 2HE8
• 分子名称: Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: 17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, closed conformation, oxidoreductase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76042.95

構造登録者

Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-the, V.,Labrie, F.,Breton, R. (登録日: 2006-06-21, 公開日: 2006-12-05, 最終更新日: 2023-08-30)

• 主引用文献: Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R.; Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.; J.Mol.Biol., 364:747-763, 2006; PubMed: 17034817; DOI: 10.1016/j.jmb.2006.09.030

実験手法

X-RAY DIFFRACTION (1.35 Å)