2HE8

Crystal structure of 17alpha-hydroxysteroid dehydrogenase in its apo-form

Summary for 2HE8

Related2HE5 2HEJ 2HDJ
DescriptorAldo-keto reductase family 1, member C21, ACETATE ION, BETA-MERCAPTOETHANOL, ... (5 entities in total)
Functional Keywords17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, apo-form, oxidoreductase
Biological sourceMus musculus (house mouse)
Total number of polymer chains2
Total molecular weight74596.01
Authors
Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-06-21, release date: 2006-12-05, Last modification date: 2011-10-05)
Primary citation
Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R.
Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.
J.Mol.Biol., 364:747-763, 2006
PubMed: 17034817 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2006.09.030
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.241100.2%2.1%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2he8
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Molmil generated image of 2he8
rotated about x axis by 90°
Molmil generated image of 2he8
rotated about y axis by 90°