2HCN

Crystal structure of RNA dependent RNA polymerase domain from west nile virus

Summary for 2HCN

• Entry DOI: 10.2210/pdb2hcn/pdb
• Descriptor: RNA-directed RNA polymerase (NS5), CALCIUM ION, ZINC ION, ... (4 entities in total)
• Functional Keywords: west-nile virus rna polymerase, structural genomics, marseilles structural genomics program @ afmb, msgp, vizier, viral enzymes involved in replication, transferase
• Biological source: Kunjin virus
• Cellular location: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P14335
• Total number of polymer chains: 1
• Total formula weight: 68502.54

Authors

Egloff, M.P.,Malet, H.,Marseilles Structural Genomics Program @ AFMB (MSGP) (deposition date: 2006-06-17, release date: 2007-02-06, Last modification date: 2023-08-30)

• Primary citation: Malet, H.,Egloff, M.P.,Selisko, B.,Butcher, R.E.,Wright, P.J.,Roberts, M.,Gruez, A.,Sulzenbacher, G.,Vonrhein, C.,Bricogne, G.,Mackenzie, J.M.,Khromykh, A.A.,Davidson, A.D.,Canard, B.; Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5; J.Biol.Chem., 282:10678-10689, 2007; PubMed: 17287213; DOI: 10.1074/jbc.M607273200

Experimental method

X-RAY DIFFRACTION (2.35 Å)