2HCI

Structure of Human Mip-3a Chemokine

2HCI の概要

• エントリーDOI: 10.2210/pdb2hci/pdb
• 関連するPDBエントリー: 1M8A
• 分子名称: Small inducible cytokine A20, SULFATE ION, SULFITE ION, ... (5 entities in total)
• 機能のキーワード: macrophage inflammatory protein-3a, dimer, space group i4, immune system
• 細胞内の位置: Secreted: P78556
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16665.54

構造登録者

Malik, Z.A.,Tack, B.F. (登録日: 2006-06-16, 公開日: 2006-07-04, 最終更新日: 2024-11-20)

主引用文献

Malik, Z.A.,Tack, B.F.
Structure of human MIP-3alpha chemokine.
Acta Crystallogr.,Sect.F, 62:631-634, 2006

PubMed Abstract: The structure of the human macrophage inflammatory protein-3alpha (MIP-3alpha) has been determined at 1.81 angstroms resolution by X-ray crystallography. The dimer crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 83.99, c = 57.20 angstroms. The crystals exhibit two molecules in the asymmetric unit. The structure was solved by the molecular-replacement method and the model was refined to a conventional R value of 20.6% (R(free) = 25.7%). MIP-3alpha possesses the same monomeric structure as previously described for other chemokines. However, in addition to limited structural changes in the beta1-beta2 hairpin of monomer B, the electron density is fully defined for a few extra residues at the N- and C-termini of monomer A and the C-terminus of monomer B compared with MIP-3alpha in space group P6(1). As the N-terminal and loop regions have been shown to be critical for receptor binding and signaling, this additional structural information may help in determining the basis of the CCR6 selectivity of MIP-3alpha.

PubMed: 16820679
DOI: 10.1107/S1744309106006890

実験手法

X-RAY DIFFRACTION (1.81 Å)