2H96

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors

2H96 の概要

関連するPDBエントリー2g01 2gmx
分子名称Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (5 entities in total)
機能のキーワードjnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, pyridine carboxamide inhibitors, transcription
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Cytoplasm (By similarity) Q9UQF2
ポリマー鎖数4
分子量合計89781.5
構造登録者
Abad-Zapatero, C. (登録日: 2006-06-09, 公開日: 2006-07-25, 最終更新日: 2011-07-13)
主引用文献
Zhao, H.,Serby, M.D.,Xin, Z.,Szczepankiewicz, B.G.,Liu, M.,Kosogof, C.,Liu, B.,Nelson, L.T.,Johnson, E.F.,Wang, S.,Pederson, T.,Gum, R.J.,Clampit, J.E.,Haasch, D.L.,Abad-Zapatero, C.,Fry, E.H.,Rondinone, C.,Trevillyan, J.M.,Sham, H.L.,Liu, G.
Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
J.Med.Chem., 49:4455-4458, 2006
PubMed: 16854050 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm060465l
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers408.2%10.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード