2H96

Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide C-jun NH2-terminal Kinase Inhibitors

2H96 の概要

• エントリーDOI: 10.2210/pdb2h96/pdb
• 関連するPDBエントリー: 2g01 2gmx
• 分子名称: Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: jnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, pyridine carboxamide inhibitors, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q9UQF2
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 89781.50

構造登録者

Abad-Zapatero, C. (登録日: 2006-06-09, 公開日: 2006-07-25, 最終更新日: 2023-08-30)

• 主引用文献: Zhao, H.,Serby, M.D.,Xin, Z.,Szczepankiewicz, B.G.,Liu, M.,Kosogof, C.,Liu, B.,Nelson, L.T.,Johnson, E.F.,Wang, S.,Pederson, T.,Gum, R.J.,Clampit, J.E.,Haasch, D.L.,Abad-Zapatero, C.,Fry, E.H.,Rondinone, C.,Trevillyan, J.M.,Sham, H.L.,Liu, G.; Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.; J.Med.Chem., 49:4455-4458, 2006; PubMed: 16854050; DOI: 10.1021/jm060465l

実験手法

X-RAY DIFFRACTION (3 Å)