2H6D

Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 chain)

2H6D の概要

• エントリーDOI: 10.2210/pdb2h6d/pdb
• 関連するPDBエントリー: 2F15
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2 (2 entities in total)
• 機能のキーワード: atp-binding; cholesterol biosynthesis; fatty acid biosynthesis;kinase; lipid synthesis; nucleotide-binding; phosphorylation; serine/threonine-protein kinase; steroid biosynthesis; sterol biosynthesis; transferase, structural genomics, structural genomics consortium, sgc, signaling protein, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P54646
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31557.75

構造登録者

Littler, D.R.,Walker, J.R.,Wybenga-Groot, L.,Newman, E.M.,Butler-Cole, C.,Mackenzie, F.,Finerty, P.J.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (登録日: 2006-05-31, 公開日: 2006-06-27, 最終更新日: 2023-08-30)

• 主引用文献: Littler, D.R.,Walker, J.R.,Davis, T.,Wybenga-Groot, L.E.,Finerty, P.J.,Newman, E.,Mackenzie, F.,Dhe-Paganon, S.; A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.; Acta Crystallogr.,Sect.F, 66:143-151, 2010; PubMed: 20124709; DOI: 10.1107/S1744309109052543

実験手法

X-RAY DIFFRACTION (1.85 Å)