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2H5S

SA2-13 penam sulfone complexed to wt SHV-1 beta-lactamase

Summary for 2H5S
Entry DOI10.2210/pdb2h5s/pdb
Related1RCJ
DescriptorSHV-1 beta-lactamase, (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total)
Functional Keywordsbeta-lactamase inhibitor, drug design, hydrolase
Biological sourceKlebsiella pneumoniae
Total number of polymer chains1
Total formula weight30289.57
Authors
van den Akker, F.,Padayatti, P.S. (deposition date: 2006-05-27, release date: 2006-10-17, Last modification date: 2023-08-30)
Primary citationPadayatti, P.S.,Sheri, A.,Totir, M.A.,Helfand, M.S.,Carey, M.P.,Anderson, V.E.,Carey, P.R.,Bethel, C.R.,Bonomo, R.A.,Buynak, J.D.,van den Akker, F.
Rational Design of a beta-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 A Crystal Structure of wt SHV-1 Complex with a Penam Sulfone.
J.Am.Chem.Soc., 128:13235-13242, 2006
Cited by
PubMed: 17017804
DOI: 10.1021/ja063715w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.28 Å)
Structure validation

217705

數據於2024-03-27公開中

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