2H5S
SA2-13 penam sulfone complexed to wt SHV-1 beta-lactamase
Summary for 2H5S
Entry DOI | 10.2210/pdb2h5s/pdb |
Related | 1RCJ |
Descriptor | SHV-1 beta-lactamase, (3R)-4-[(4-CARBOXYBUTANOYL)OXY]-N-[(1E)-3-OXOPROP-1-EN-1-YL]-3-SULFINO-D-VALINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (4 entities in total) |
Functional Keywords | beta-lactamase inhibitor, drug design, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30289.57 |
Authors | van den Akker, F.,Padayatti, P.S. (deposition date: 2006-05-27, release date: 2006-10-17, Last modification date: 2023-08-30) |
Primary citation | Padayatti, P.S.,Sheri, A.,Totir, M.A.,Helfand, M.S.,Carey, M.P.,Anderson, V.E.,Carey, P.R.,Bethel, C.R.,Bonomo, R.A.,Buynak, J.D.,van den Akker, F. Rational Design of a beta-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 A Crystal Structure of wt SHV-1 Complex with a Penam Sulfone. J.Am.Chem.Soc., 128:13235-13242, 2006 Cited by PubMed: 17017804DOI: 10.1021/ja063715w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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