2H5L

S-Adenosylhomocysteine hydrolase containing NAD and 3-deaza-D-eritadenine

2H5L の概要

• エントリーDOI: 10.2210/pdb2h5l/pdb
• 分子名称: Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-2,3-DIHYDROXYBUTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: s-adenosylhomocysteine, hydrolase, inhibitor, hypocholesterolemic activity
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cytoplasm: P10760
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 387050.90

構造登録者

Yamada, T.,Komoto, J.,Takusagawa, F. (登録日: 2006-05-26, 公開日: 2007-04-10, 最終更新日: 2024-02-14)

• 主引用文献: Yamada, T.,Komoto, J.,Lou, K.,Ueki, A.,Hua, D.H.,Sugiyama, K.,Takata, Y.,Ogawa, H.,Takusagawa, F.; Structure and function of eritadenine and its 3-deaza analogues: Potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.; Biochem.Pharm., 73:981-989, 2007; PubMed: 17214973; DOI: 10.1016/j.bcp.2006.12.014

実験手法

X-RAY DIFFRACTION (2.8 Å)