2H5D
0.9A resolution crystal structure of alpha-lytic protease complexed with a transition state analogue, MeOSuc-Ala-Ala-Pro-Val boronic acid
2H5D の概要
エントリーDOI | 10.2210/pdb2h5d/pdb |
関連するPDBエントリー | 1P03 1QRX 1SSX 1TAL 2H5C 2ULL |
関連するBIRD辞書のPRD_ID | PRD_000316 |
分子名称 | ALPHA-LYTIC PROTEASE, MEOSUC-ALA-ALA-PRO-ALA BORONIC ACID INHIBITOR, SULFATE ION, ... (5 entities in total) |
機能のキーワード | a-lytic protease, serine protease, acylation transition state, catalysis, protein folding, protein stability, packing distortion, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Lysobacter enzymogenes |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 21206.05 |
構造登録者 | |
主引用文献 | Fuhrmann, C.N.,Daugherty, M.D.,Agard, D.A. Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis J.Am.Chem.Soc., 128:9086-9102, 2006 Cited by PubMed: 16834383DOI: 10.1021/ja057721o 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (0.9 Å) |
構造検証レポート
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