2H3B

Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1

Summary for 2H3B

• Entry DOI: 10.2210/pdb2h3b/pdb
• Related: 2H3D
• Descriptor: Nicotinamide phosphoribosyltransferase, SULFATE ION (3 entities in total)
• Functional Keywords: apoenzyme, type ii phsophoribosyltransferase, transferase
• Biological source: Mus musculus (house mouse)
• Cellular location: Cytoplasm: Q99KQ4
• Total number of polymer chains: 2
• Total formula weight: 112507.07

Authors

Wang, T.,Zhang, X.,Bheda, P.,Revollo, J.R.,Imai, S.I.,Wolberger, C. (deposition date: 2006-05-22, release date: 2006-06-20, Last modification date: 2024-11-20)

Primary citation

Wang, T.,Zhang, X.,Bheda, P.,Revollo, J.R.,Imai, S.I.,Wolberger, C.
Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme.
Nat.Struct.Mol.Biol., 13:661-662, 2006

PubMed Abstract: Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

PubMed: 16783373
DOI: 10.1038/nsmb1114

Experimental method

X-RAY DIFFRACTION (1.95 Å)