2H2Q

Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase

Summary for 2H2Q

• Entry DOI: 10.2210/pdb2h2q/pdb
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (4 entities in total)
• Functional Keywords: bifunctional enzyme in complex with nadp and dump, oxidoreductase, transferase
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 2
• Total formula weight: 119911.32

Authors

Senkovich, O.,Schormann, N.,Chattopadhyay, D. (deposition date: 2006-05-19, release date: 2008-04-08, Last modification date: 2023-08-30)

• Primary citation: Schormann, N.,Senkovich, O.,Walker, K.,Wright, D.L.,Anderson, A.C.,Rosowsky, A.,Ananthan, S.,Shinkre, B.,Velu, S.,Chattopadhyay, D.; Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.; Proteins, 73:889-901, 2008; PubMed: 18536013; DOI: 10.1002/prot.22115

Experimental method

X-RAY DIFFRACTION (2.4 Å)