2H2Q

Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase

2H2Q の概要

• エントリーDOI: 10.2210/pdb2h2q/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: bifunctional enzyme in complex with nadp and dump, oxidoreductase, transferase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119911.32

構造登録者

Senkovich, O.,Schormann, N.,Chattopadhyay, D. (登録日: 2006-05-19, 公開日: 2008-04-08, 最終更新日: 2023-08-30)

• 主引用文献: Schormann, N.,Senkovich, O.,Walker, K.,Wright, D.L.,Anderson, A.C.,Rosowsky, A.,Ananthan, S.,Shinkre, B.,Velu, S.,Chattopadhyay, D.; Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.; Proteins, 73:889-901, 2008; PubMed: 18536013; DOI: 10.1002/prot.22115

実験手法

X-RAY DIFFRACTION (2.4 Å)