2H2I

The Structural basis of Sirtuin Substrate Affinity

Summary for 2H2I

• Entry DOI: 10.2210/pdb2h2i/pdb
• Descriptor: NAD-dependent deacetylase, ZINC ION, (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL, ... (4 entities in total)
• Functional Keywords: sir2tm-ppg, hydrolase
• Biological source: Thermotoga maritima
• Cellular location: Cytoplasm (By similarity): Q9WYW0
• Total number of polymer chains: 1
• Total formula weight: 28059.77

Authors

Cosgrove, M.S.,Wolberger, C. (deposition date: 2006-05-18, release date: 2006-12-05, Last modification date: 2023-08-30)

• Primary citation: Cosgrove, M.S.,Bever, K.,Avalos, J.L.,Muhammad, S.,Zhang, X.,Wolberger, C.; The structural basis of sirtuin substrate affinity; Biochemistry, 45:7511-7521, 2006; PubMed: 16768447; DOI: 10.1021/bi0526332

Experimental method

X-RAY DIFFRACTION (1.8 Å)