2H15

Carbonic anhydrase inhibitors: Clashing with Ala65 as a means of designing isozyme-selective inhibitors that show low affinity for the ubiquitous isozyme II

2H15 の概要

• エントリーDOI: 10.2210/pdb2h15/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitors, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29893.44

構造登録者

Winum, J.Y.,Temperini, C.,Ciattini, S.,Scozzafava, A.,Supuran, C.T. (登録日: 2006-05-16, 公開日: 2007-03-27, 最終更新日: 2024-02-14)

• 主引用文献: Winum, J.Y.,Temperini, C.,El Cheikh, K.,Innocenti, A.,Vullo, D.,Ciattini, S.,Montero, J.L.,Scozzafava, A.,Supuran, C.T.; Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.; J.Med.Chem., 49:7024-7031, 2006; PubMed: 17125255; DOI: 10.1021/jm060807n

実験手法

X-RAY DIFFRACTION (1.9 Å)