2H04

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

2H04 の概要

• エントリーDOI: 10.2210/pdb2h04/pdb
• 関連するPDBエントリー: 2HO2 2HO3
• 分子名称: Protein tyrosine phosphatase, receptor type, B,, {4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACID (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, wpd-loop, sulfamic acid, phosphatase, inhibitor, drug design, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36743.52

構造登録者

Evdokimov, A.G.,Pokross, M.E.,Walter, R.L.,Mekel, M.,Gray, J.L.,Peters, K.G.,Maier, M.B.,Amarasinghe, K.D.,Clark, C.M.,Nichols, R. (登録日: 2006-05-13, 公開日: 2006-06-13, 最終更新日: 2023-08-30)

主引用文献

Amarasinghe, K.K.,Evdokimov, A.G.,Xu, K.,Clark, C.M.,Maier, M.B.,Srivastava, A.,Colson, A.O.,Gerwe, G.S.,Stake, G.E.,Howard, B.W.,Pokross, M.E.,Gray, J.L.,Peters, K.G.
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Bioorg.Med.Chem.Lett., 16:4252-4256, 2006

PubMed Abstract: The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.

PubMed: 16759857
DOI: 10.1016/j.bmcl.2006.05.074

実験手法

X-RAY DIFFRACTION (2.3 Å)