2GYP
Diabetes mellitus due to a frustrated Schellman motif in HNF-1a
Summary for 2GYP
Entry DOI | 10.2210/pdb2gyp/pdb |
Related | 1g2y 1g2z 1g39 1JB6 |
Descriptor | Hepatocyte nuclear factor 1-alpha (2 entities in total) |
Functional Keywords | energy landscape, gene regulation, protein engineering, protein stability, protein structure, transcription regulator |
Total number of polymer chains | 2 |
Total formula weight | 7138.30 |
Authors | Narayana, N.,Phillips, N.B.,Hua, Q.X.,Jia, W.,Weiss, M.A. (deposition date: 2006-05-09, release date: 2007-03-20, Last modification date: 2023-11-15) |
Primary citation | Narayana, N.,Phillips, N.B.,Hua, Q.X.,Jia, W.,Weiss, M.A. Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha. J.Mol.Biol., 362:414-429, 2006 Cited by PubMed: 16930618DOI: 10.1016/j.jmb.2006.06.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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