2GYP

Diabetes mellitus due to a frustrated Schellman motif in HNF-1a

2GYP の概要

• エントリーDOI: 10.2210/pdb2gyp/pdb
• 関連するPDBエントリー: 1JB6 1g2y 1g2z 1g39
• 分子名称: Hepatocyte nuclear factor 1-alpha (2 entities in total)
• 機能のキーワード: energy landscape, gene regulation, protein engineering, protein stability, protein structure, transcription regulator
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7138.30

構造登録者

Narayana, N.,Phillips, N.B.,Hua, Q.X.,Jia, W.,Weiss, M.A. (登録日: 2006-05-09, 公開日: 2007-03-20, 最終更新日: 2023-11-15)

• 主引用文献: Narayana, N.,Phillips, N.B.,Hua, Q.X.,Jia, W.,Weiss, M.A.; Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha.; J.Mol.Biol., 362:414-429, 2006; PubMed: 16930618; DOI: 10.1016/j.jmb.2006.06.086

実験手法

X-RAY DIFFRACTION (1.4 Å)