2GX9
X-ray structure of influenza virus NS1 effector domain
Summary for 2GX9
| Entry DOI | 10.2210/pdb2gx9/pdb |
| Descriptor | NS1 Effector Domain, THIOCYANATE ION (3 entities in total) |
| Functional Keywords | ns1, influenza, effector domain, alpha-helix beta-crescent, transcription, virus-viral protein complex, virus/viral protein |
| Biological source | unidentified influenza virus |
| Total number of polymer chains | 2 |
| Total formula weight | 29648.11 |
| Authors | Bornholdt, Z.A.,Prasad, B.V. (deposition date: 2006-05-08, release date: 2006-05-30, Last modification date: 2024-10-30) |
| Primary citation | Bornholdt, Z.A.,Prasad, B.V. X-ray structure of influenza virus NS1 effector domain. Nat.Struct.Mol.Biol., 13:559-560, 2006 Cited by PubMed Abstract: The nonstructural protein NS1 of influenza virus is an antagonist of host immune responses and is implicated in virulence. It has two domains, an N-terminal double-stranded RNA-binding domain (RBD) and an effector domain crucial for RBD function, for nuclear export and for sequestering messenger RNA-processing proteins. Here we present the crystallographic structure of the effector domain, which has a novel fold and suggests mechanisms for increased virulence in H5N1 strains. PubMed: 16715094DOI: 10.1038/nsmb1099 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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