2GW1

Crystal Structure of the Yeast Tom70

2GW1 の概要

• エントリーDOI: 10.2210/pdb2gw1/pdb
• 分子名称: Mitochondrial precursor proteins import receptor (2 entities in total)
• 機能のキーワード: tpr, protein transport
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Mitochondrion outer membrane ; Single-pass membrane protein : P07213
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117620.42

構造登録者

Wu, Y.,Sha, B. (登録日: 2006-05-03, 公開日: 2006-06-27, 最終更新日: 2024-11-13)

主引用文献

Wu, Y.,Sha, B.
Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p.
Nat.Struct.Mol.Biol., 13:589-593, 2006

PubMed Abstract: A majority of the proteins targeted to the mitochondria are transported through the translocase of the outer membrane (TOM) complex. Tom70 is a major surface receptor for mitochondrial protein precursors in the TOM complex. To investigate how Tom70 receives the mitochondrial protein precursors, we have determined the crystal structure of yeast Tom70p to 3.0 A. Tom70p forms a homodimer in the crystal. Each subunit consists primarily of tetratricopeptide repeat (TPR) motifs, which are organized into a right-handed superhelix. The TPR motifs in the N-terminal domain of Tom70p form a peptide-binding groove for the C-terminal EEVD motif of Hsp70, whereas the C-terminal domain of Tom70p contains a large pocket that may be the binding site for mitochondrial precursors. The crystal structure of Tom70p provides insights into the mechanisms of precursor transport across the mitochondrion's outer membrane.

PubMed: 16767096
DOI: 10.1038/nsmb1106

実験手法

X-RAY DIFFRACTION (3 Å)