Crystal Structure of Murine NMPRTase

Summary for 2GVL

DescriptorNicotinamide phosphoribosyltransferase (2 entities in total)
Functional Keywordsvisfatin, pbef, nmprtase, cancer, fk866, transferase
Biological sourceMus musculus (house mouse)
Cellular locationCytoplasm Q99KQ4
Total number of polymer chains2
Total molecular weight111137.13
Khan, J.A.,Tao, X.,Tong, L. (deposition date: 2006-05-02, release date: 2006-07-25, Last modification date: 2011-07-13)
Primary citation
Khan, J.A.,Tao, X.,Tong, L.
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.
Nat.Struct.Mol.Biol., 13:582-588, 2006
PubMed: 16783377 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb1105
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233604.3%6.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2gvl
no rotation
Molmil generated image of 2gvl
rotated about x axis by 90°
Molmil generated image of 2gvl
rotated about y axis by 90°