2GVJ

Crystal Structure of Human NMPRTase in complex with FK866

Summary for 2GVJ

Related2GVG
DescriptorNicotinamide phosphoribosyltransferase, (2E)-N-{4-[1-(benzenecarbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide (3 entities in total)
Functional Keywordsnmprtase, visfatin, pbef, cancer, fk866, transferase
Biological sourceHomo sapiens (human)
Cellular locationNucleus  P43490
Total number of polymer chains2
Total molecular weight112254.25
Authors
Khan, J.A.,Tao, X.,Tong, L. (deposition date: 2006-05-02, release date: 2006-06-20, Last modification date: 2016-11-09)
Primary citation
Khan, J.A.,Tao, X.,Tong, L.
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.
Nat.Struct.Mol.Biol., 13:582-588, 2006
PubMed: 16783377 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb1105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252100.4%5.4%9.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution