2GV7

Structure of Matriptase in Complex with Inhibitor CJ-672

Summary for 2GV7

Entry DOI	10.2210/pdb2gv7/pdb
Related	2GV6
Descriptor	Suppressor of tumorigenicity 14, (S)-4-(4-(3-(3-CARBAMIMIDOYLPHENYL)-2-(2,4,6-TRIISOPROPYLPHENYLSULFONAMIDO)PROPANOYL)PIPERAZINE-1-CARBONYL)PIPERIDINE-1-CARBOXIMIDAMIDE (3 entities in total)
Functional Keywords	matriptase, inhibitor, complex structure, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type II membrane protein (Probable): Q9Y5Y6
Total number of polymer chains	1
Total formula weight	27158.69
Authors	Bode, W. (deposition date: 2006-05-02, release date: 2006-06-06, Last modification date: 2011-07-13)
Primary citation	Steinmetzer, T.,Schweinitz, A.,Sturzebecher, A.,Donnecke, D.,Uhland, K.,Schuster, O.,Steinmetzer, P.,Muller, F.,Friedrich, R.,Than, M.E.,Bode, W.,Sturzebecher, J. Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase. J.Med.Chem., 49:4116-4126, 2006 Cited by PubMed: 16821772 DOI: 10.1021/jm051272l PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation