2GUM

Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I

2GUM の概要

• エントリーDOI: 10.2210/pdb2gum/pdb
• 分子名称: Glycoprotein B, SODIUM ION (3 entities in total)
• 機能のキーワード: envelope glycoprotein, membrane fusion, viral protein
• 由来する生物種: Human herpesvirus 1
• 細胞内の位置: Virion membrane ; Single-pass type I membrane protein : P06437
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 215096.52

構造登録者

Heldwein, E.E. (登録日: 2006-05-01, 公開日: 2006-07-25, 最終更新日: 2024-11-06)

主引用文献

Heldwein, E.E.,Lou, H.,Bender, F.C.,Cohen, G.H.,Eisenberg, R.J.,Harrison, S.C.
Crystal structure of glycoprotein B from herpes simplex virus 1.
Science, 313:217-220, 2006

PubMed Abstract: Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.

PubMed: 16840698
DOI: 10.1126/science.1126548

実験手法

X-RAY DIFFRACTION (2.1 Å)