2GTP

Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1

Summary for 2GTP

Entry DOI	10.2210/pdb2gtp/pdb
Descriptor	Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signaling 1, TETRAFLUOROALUMINATE ION, ... (6 entities in total)
Functional Keywords	g protein signalling, rgs, heterotrimeric g protein, signalling complex, structural genomics, structural genomics consortium, sgc, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (By similarity): P63096
Total number of polymer chains	4
Total formula weight	108354.99
Authors	Soundararajan, M.,Turnbull, A.P.,Ugochukwu, E.,Gorrec, F.,von Delft, F.,Weigelt, J.,Edwards, A.,Arrowsmith, C.,Sundstrom, M.,Doyle, D.A.,Structural Genomics Consortium (SGC) (deposition date: 2006-04-28, release date: 2006-05-23, Last modification date: 2023-08-30)
Primary citation	Soundararajan, M.,Willard, F.S.,Kimple, A.J.,Turnbull, A.P.,Ball, L.J.,Schoch, G.A.,Gileadi, C.,Fedorov, O.Y.,Dowler, E.F.,Higman, V.A.,Hutsell, S.Q.,Sundstrom, M.,Doyle, D.A.,Siderovski, D.P. Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105:6457-6462, 2008 Cited by PubMed: 18434541 DOI: 10.1073/pnas.0801508105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation