2GTK
Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists
Summary for 2GTK
Entry DOI | 10.2210/pdb2gtk/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Decamer from Nuclear receptor coactivator 1, (2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID, ... (4 entities in total) |
Functional Keywords | nuclear receptor, transcription regulator |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P37231 Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 32591.31 |
Authors | Kuhn, B.,Hilpert, H.,Benz, J.,Binggeli, A.,Grether, U.,Humm, R.,Maerki, H.-P.,Meyer, M.,Mohr, P. (deposition date: 2006-04-28, release date: 2006-09-26, Last modification date: 2024-04-03) |
Primary citation | Kuhn, B.,Hilpert, H.,Benz, J.,Binggeli, A.,Grether, U.,Humm, R.,Meyer, M.,Mohr, P. Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists Bioorg.Med.Chem.Lett., 16:4016-4020, 2006 Cited by PubMed: 16737814DOI: 10.1016/j.bmcl.2006.05.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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