2GTI

mutation of MHV coronavirus non-structural protein nsp15 (F307L)

2GTI の概要

• エントリーDOI: 10.2210/pdb2gti/pdb
• 分子名称: Replicase polyprotein 1ab, SULFATE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: mhv, nsp15, f307l, viral protein
• 由来する生物種: Murine hepatitis virus
• 細胞内の位置: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P16342
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42850.35

構造登録者

Xu, X.,Zhai, Y.,Sun, F.,Lou, Z.,Su, D.,Rao, Z. (登録日: 2006-04-28, 公開日: 2006-08-15, 最終更新日: 2021-11-10)

• 主引用文献: Xu, X.,Zhai, Y.,Sun, F.,Lou, Z.,Su, D.,Xu, Y.,Zhang, R.,Joachimiak, A.,Zhang, X.C.,Bartlam, M.,Rao, Z.; New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15; J.Virol., 80:7909-7917, 2006; PubMed: 16873248; DOI: 10.1128/JVI.00525-06

実験手法

X-RAY DIFFRACTION (2.15 Å)