2GT7
Crystal structure of SARS coronavirus main peptidase at pH 6.0 in the space group P21
Summary for 2GT7
Entry DOI | 10.2210/pdb2gt7/pdb |
Related | 2GT8 2GTB |
Descriptor | 3C-like proteinase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID (3 entities in total) |
Functional Keywords | cysteine peptidase, 3c-like, n-finger, chymotrypsin-like fold, long loop, alpha-helical domain, dimer, catalytic dyad, specificity pockets, hydrolase |
Biological source | SARS coronavirus |
Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641 |
Total number of polymer chains | 2 |
Total formula weight | 67948.51 |
Authors | Lee, T.-W.,Cherney, M.M.,Huitema, C.,Liu, J.,James, K.E.,Powers, J.C.,Eltis, L.D.,James, M.N.G. (deposition date: 2006-04-27, release date: 2006-12-26, Last modification date: 2024-02-14) |
Primary citation | Lee, T.W.,Cherney, M.M.,Liu, J.,James, K.E.,Powers, J.C.,Eltis, L.D.,James, M.N.G. Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase. J.Mol.Biol., 366:916-932, 2007 Cited by PubMed: 17196984DOI: 10.1016/j.jmb.2006.11.078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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