2GPR

GLUCOSE PERMEASE IIA FROM MYCOPLASMA CAPRICOLUM

2GPR の概要

• エントリーDOI: 10.2210/pdb2gpr/pdb
• 分子名称: GLUCOSE-PERMEASE IIA COMPONENT (2 entities in total)
• 機能のキーワード: phosphotransferase, glucose permease, enzyme iia, mycoplasma
• 由来する生物種: Mycoplasma capricolum
• 細胞内の位置: Cytoplasm: P45618
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16723.24

構造登録者

Huang, K.,Herzberg, O. (登録日: 1998-05-19, 公開日: 1998-08-12, 最終更新日: 2024-05-29)

主引用文献

Huang, K.,Kapadia, G.,Zhu, P.P.,Peterkofsky, A.,Herzberg, O.
A promiscuous binding surface: crystal structure of the IIA domain of the glucose-specific permease from Mycoplasma capricolum.
Structure, 6:697-710, 1998

PubMed Abstract: The phosphoenolpyruvate:sugar phosphotransferase system (PTS) is a bacterial and mycoplasma system responsible for the uptake of some sugars, concomitant with their phosphorylation. The sugar-specific component of the system, enzyme II (EII),consists of three domains, EIIA, EIIB and EIIC. EIIA and ELLB are cytoplasmic and EIIC is an integral membrane protein that contains the sugar-binding site. Phosphoenolpyruvate (PEP) provides the source of the phosphoryl group, which is transferred via several phosphoprotein intermediates, eventually being transferred to the internalized sugar. Along the pathway, EIIA accepts a phosphoryl group from the phosphocarrier protein HPr and transfers it to EIIB. The structure of the glucose-specific EIIA (EIIAglc) from Mycoplasma capricolum reported here facilitates understanding of the nature of the interactions between this protein and its partners.

PubMed: 9705652
DOI: 10.1016/S0969-2126(98)00072-0

実験手法

X-RAY DIFFRACTION (2.5 Å)