2GLW

The solution structure of PHS018 from pyrococcus horikoshii

2GLW の概要

• エントリーDOI: 10.2210/pdb2glw/pdb
• NMR情報: BMRB: 7116
• 分子名称: 92aa long hypothetical protein (1 entity in total)
• 機能のキーワード: rift barrel, bioinformatics, transcription
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10302.03

構造登録者

Coles, M.,Hulko, M.,Truffault, V.,Martin, J.,Lupas, A.N. (登録日: 2006-04-05, 公開日: 2006-12-05, 最終更新日: 2024-05-01)

主引用文献

Coles, M.,Hulko, M.,Djuranovic, S.,Truffault, V.,Koretke, K.,Martin, J.,Lupas, A.N.
Common evolutionary origin of swapped-hairpin and double-psi beta barrels
Structure, 14:1489-1498, 2006

PubMed Abstract: The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.

PubMed: 17027498
DOI: 10.1016/j.str.2006.08.005

実験手法

SOLUTION NMR