2GJX
Crystallographic structure of human beta-Hexosaminidase A
Summary for 2GJX
Entry DOI | 10.2210/pdb2gjx/pdb |
Related | 2GK1 |
Descriptor | Beta-hexosaminidase alpha chain, Beta-hexosaminidase beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | beta-hexosaminidase a, glycosidase, tay-sachs disease, gm2 ganglisode, tim barrel, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 472992.25 |
Authors | Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N.G. (deposition date: 2006-03-31, release date: 2006-06-20, Last modification date: 2024-10-09) |
Primary citation | Lemieux, M.J.,Mark, B.L.,Cherney, M.M.,Withers, S.G.,Mahuran, D.J.,James, M.N.G. Crystallographic structure of human beta-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis J.Mol.Biol., 359:913-929, 2006 Cited by PubMed: 16698036DOI: 10.1016/j.jmb.2006.04.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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