2GFS
P38 Kinase Crystal Structure in complex with RO3201195
Summary for 2GFS
Entry DOI | 10.2210/pdb2gfs/pdb |
Descriptor | Mitogen-Activated Protein Kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE (3 entities in total) |
Functional Keywords | p38; map kinase; serine/threonine kinase, signaling protein, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 43120.08 |
Authors | Harris, S.F.,Bertrand, J.,Villasenor, A. (deposition date: 2006-03-23, release date: 2006-04-18, Last modification date: 2024-02-14) |
Primary citation | Goldstein, D.M.,Alfredson, T.A.,Bertrand, J.,Browner, M.F.,Clifford, K.,Dalrymple, S.,Dunn, J.,Freire-Moare, J.,Harris, S.F.,Labadie, S.S.,La Fargue, J.,Lapierre, J.M.,Larrabee, S.,Li, F.,Papp, E.,McWeeney, D.,Ramesha, C.,Roberts, R.,Rotstein, D.,San Pablo, B.,Sjogren, E.,So, O.Y.,Talamas, F.X.,Tao, W.,Trejo, A.,Villasenor, A.,Welch, M.,Welch, T.,Weller, P.,Whiteley, P.E.,Young, K.,Zipfel, S. Discovery of S-[5-Amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]-methanone (RO3201195), and Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase J.Med.Chem., 49:1562-1575, 2006 Cited by PubMed: 16509574DOI: 10.1021/jm050736c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.752 Å) |
Structure validation
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